![]() ![]() Further studies are necessary to validate this index in other settings.Īge-associated systolic hypertension, a disproportional increase in systolic blood pressure (BP) while maintaining a relatively normal or even decreased diastolic BP, has consistently been linked with increased cardiovascular morbidity and mortality. Considering the limitations of the currently available indices of arterial stiffness, we propose a novel index of intrinsic arterial stiffness, the ASI, which is robust over a range of BPs and allows one to distinguish between compliant and stiff vasculature in both Fisher rats and SHRs. The novel Arterial Stiffness Index (ASI) differentiated stiffer from more compliant vasculature. The previously described Ambulatory Arterial Stiffness Index (AASI) was able to differentiate between young and old vasculature, whereas the Cardio-Ankle Vascular Index (CAVI) did not reliably differentiate between the two. Age markedly changes the relationship between PWV or PP and BP. ![]() Both PWV and PP increase in a non-linear manner with rising BP for both strains of animals (Fisher and SHRs). An index incorporating PWV and PP was also constructed. The BP dependence of these and several other indices of vascular stiffness were evaluated. PWV and PP were measured in young and old male Fisher rats and in young and old male spontaneously hypertensive rats (SHR) over a wide range of BPs. Considering that there are no clinically useful markers for arterial stiffness that are BP-independent, our objective was to identify novel indices of arterial stiffness and compare them with previously described markers. Pulse wave velocity (PWV) and pulse pressure (PP) are blood pressure (BP)-dependent surrogates for vascular stiffness. ![]()
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